Model explorer
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The time machine's minimal compartmental model with cited physiological parameters, ported to run in the browser. Pick a compound, a predefined virtual population and a dose and schedule within the model's fixed bounds; the result is the spread of plasma concentrations over hundreds of virtual individuals.
Virtual population, for research. Not about any person and not a dose recommendation.
In silico and exploratory: a model output for teaching and research. It describes a simulated group, never someone's own body, and it says nothing about what anyone should take.
How well the model matched published data for amlodipine
Borderline
Model peak 2.37-fold lower than published; area under the curve 1.39-fold lower.
Checked against one 10 mg dose in healthy volunteers (Soria-Chacartegui 2023); other doses and schedules are not checked.
Between 2- and 3-fold: read the shape and the spread, not the absolute numbers.
Result
Line: median of the virtual individuals. Shaded band: 5th to 95th percentile. There is no curve for any single person.
Show the numbers as a table
| Hour | P5 | Median | P95 |
|---|---|---|---|
| 0 | 0 | 0 | 0 |
| 1 | 0.638 | 1.48 | 3.27 |
| 2 | 1.37 | 2.71 | 4.78 |
| 3 | 1.87 | 3.28 | 5.35 |
| 4 | 2.12 | 3.59 | 5.67 |
| 5 | 2.28 | 3.71 | 5.65 |
| 6 | 2.39 | 3.76 | 5.78 |
| 7 | 2.44 | 3.75 | 5.75 |
| 8 | 2.41 | 3.71 | 5.66 |
| 9 | 2.41 | 3.66 | 5.61 |
| 10 | 2.4 | 3.6 | 5.47 |
| 11 | 2.37 | 3.55 | 5.32 |
| 12 | 2.36 | 3.48 | 5.25 |
| 13 | 2.33 | 3.41 | 5.12 |
| 14 | 2.28 | 3.33 | 4.96 |
| 15 | 2.23 | 3.26 | 4.8 |
| 16 | 2.19 | 3.2 | 4.71 |
| 17 | 2.14 | 3.13 | 4.6 |
| 18 | 2.1 | 3.07 | 4.52 |
| 19 | 2.07 | 3.01 | 4.47 |
| 20 | 2.03 | 2.95 | 4.34 |
| 21 | 1.99 | 2.88 | 4.23 |
| 22 | 1.94 | 2.82 | 4.14 |
| 23 | 1.88 | 2.77 | 4.05 |
| 24 | 1.82 | 2.71 | 3.98 |
| 25 | 1.8 | 2.66 | 3.89 |
| 26 | 1.74 | 2.6 | 3.8 |
| 27 | 1.69 | 2.55 | 3.72 |
| 28 | 1.65 | 2.5 | 3.64 |
| 29 | 1.62 | 2.45 | 3.57 |
| 30 | 1.59 | 2.38 | 3.51 |
| 31 | 1.55 | 2.33 | 3.44 |
| 32 | 1.51 | 2.29 | 3.38 |
| 33 | 1.48 | 2.25 | 3.31 |
| 34 | 1.43 | 2.2 | 3.25 |
| 35 | 1.39 | 2.16 | 3.22 |
| 36 | 1.33 | 2.11 | 3.18 |
| 37 | 1.3 | 2.07 | 3.15 |
| 38 | 1.27 | 2.03 | 3.08 |
| 39 | 1.24 | 2 | 3.01 |
| 40 | 1.19 | 1.96 | 2.97 |
| 41 | 1.13 | 1.92 | 2.91 |
| 42 | 1.07 | 1.88 | 2.85 |
| 43 | 1.03 | 1.84 | 2.81 |
| 44 | 1 | 1.8 | 2.78 |
| 45 | 0.968 | 1.77 | 2.73 |
| 46 | 0.935 | 1.74 | 2.7 |
| 47 | 0.904 | 1.71 | 2.67 |
| 48 | 0.874 | 1.67 | 2.64 |
- Highest concentration in the simulated time: median 3.86 ng/mL, 90% of virtual individuals between 2.47 and 5.87 ng/mL.
- Area under the curve of one dose: median 218 ng·h/mL, 90% of virtual individuals between 129 and 381 ng·h/mL.
No calibrated interval: the bands show the spread of the virtual population, not the model's error. Concentrations, peaks and areas are not validated against measured data beyond the one study above.
Virtual population, for research. Not about any person and not a dose recommendation.
In silico and exploratory: a model output for teaching and research. It describes a simulated group, never someone's own body, and it says nothing about what anyone should take.